Bank Fraud, like mail and wire fraud, involves getting money or property that shouldn't be obtained.  Unlike mail and wire fraud, the statute covering bank fraud, 18 U.S.C. § 1344, isn't convoluted and full of nested clauses that cross the eyes of the average resident of the United States.  The actual language of section 1344 is:

Whoever knowingly executes, or attempts to execute, a scheme or artifice—

1. to defraud a financial institution; or
2. to obtain any of the moneys, funds, credits, assets, securities, or other property owned by, or under the custody or control of, a financial institution, by means of false or fraudulent pretenses, representations, or promises;

shall be fined not more than $1,000,000 or imprisoned not more than 30 years, or both.

At least the statute is largely understandable.  But the same questions that arise under the mail and wire fraud statutes are present vis-a-vis bank fraud: what does it mean to defraud? to obtain X by means of false or fraudulent pretenses?  does it matter where the case it brought? up to 30 years is a long time, so what am I really looking at?  That's why it is so important when dealing with a federal prosecution to have an attorney who is familiar and comfortable with federal criminal defense, and who has appeared in federal courthouses across the country.